毒性及關注化學物質管理法於108年1月16日修正，第四類毒性化學物質定義為：「化學物質具有內分泌干擾素特性或有污染環境、危害人體健康者。」國際間對內分泌干擾素都有不同的法規規範，其定義的鬆緊可直接影響到後續管理措施及成效，本計畫旨在研析國內對內分泌干擾素的相關管理建議。「干擾素」有特定意義，建議可以將「內分泌干擾素」更名為「內分泌干擾物」。世界各國對「內分泌干擾素」有不同之定義：有廣義的定義，有強調負面效應的定義，亦有著重在干擾機制的定義，而臺灣的定義則包含上述所有特性。本計畫建議「內分泌干擾素」特性的定義能以廣義方式來進行，以保持彈性。而各國對「內分泌干擾素」的篩選有不同的考量，建議可參考OECD的概念分5階段評估，但應加入國內「內分泌干擾素」流行病學資料及國內使用量。另外，比對各國內分泌干擾素清單與我國毒性及關注化學物質管理法列管340種化學物質，其中第一類、第二類及第三類毒性化學物質有78種與其他國家公告的疑似內分泌干擾素清單重疊，第四類毒性化學物質中有27個似符合其他國家內分泌干擾素定義，未來可持續收集國際管理資訊及國內運作情形，以評估增列第四類毒性化學物質分類或關注化學物質。

Toxic and Concerned Chemical Substances Control Act (TCCSC Act) was amended on Jan 16, 2019. Class 4 toxic chemical substances were defined as those chemical substances that have endocrine disruptor properties, environmental pollutants or chemicals which endanger human health. Every country has its own definition on endocrine disruptors (EDs), and the stringency of definition of EDs will consequently affect the related industries. To this aim, this project is designed to study the EDs related issues in Taiwan. The definitions of EDs throughout the world are different, some countries use extended definitions, some other countries define the EDs on its adverse effects, and some emphasize the interfering mechanisms of EDs. The definition of EDs in Taiwan is the summary of all the above definitions. This project recommends the using of extended definition of EDs at this moment, and the flexibility is the advantage. The screening methods for the identification of EDs are different around the world. This project recommends to follow the 5 levels of EDs screening strategy by OECD. In addition, the results of local epidemiological studies and the exposure potential (the amount used per year) should be included in the final evaluation. Around the world, every country has its own EDs list. In Taiwan, the TCCSC has registered 340 chemicals as the toxic substances. Among this 340 chemicals, 78 chemicals of class 1, class 2, or class 3 have been identified as EDs by other countries. In addition, 27 of class 4 chemicals in TCCSC has been identified as EDs by other countries. The above chemicals can be evaluated to be declared as “potential EDs” or listed as “concerned chemicals.”